Synthesis, In vitro Cytotoxicity, Molecular docking of Few Quinazolinone Incorporated Naphthyl Chalcones: As Potential Dual Targeting Anticancer Agents to Treat Lung Cancer and Colorectal Cancer

The present study is an effort to explore some low molecular weight chemical entities quinazolinone incorporated naphthyl chalcones for their cytotoxic potential and, that can act smartly by inhibiting the mutated targets EGFR (T790M mutation; PDB Id: 5Y9T), and K-RAS(G12D 4EPT). in-vitro studies were done MTT assay method. For lung cancer cell lines (A549), N1-N4 found as more potent than reference erlotinib (IC50:44.4μg/ml), among them, most compound N3 (IC50:11.29 μg/ml). Against colorectal (Caco2), same was (IC50:10.79 Molecular docking autodock-4 revealed all title compounds have high affinity both targets, they negative binding energies. inhibition constants obtained in are nanomoles, be used a template developing potent, selective dual targeted drugs treat cancer.